143 - Exploring Relationships Between Medication and Supplement Intake and Childhood Caries

Purpose: To investigate relationships between medication and supplement intake (antibiotics, over-the counter (OTC) medications, vitamins) and caries in young children. This study is part of a pilot study exploring associations between oral and gut microbiomes, dietary intake, environmental exposures, and early childhood caries. 

Methods: Twenty-four three-year-old children (ECC=14) and parents/caregivers (over 18 years) were recruited after routine examinations at Columbia University’s teaching clinics. A survey assessed parent-reported bio-behavioral (e.g., diet, medication and supplement use, dental and general health history) and socio-environmental exposures (e.g., household characteristics). Clinical data documented per clinic protocol included caries (total dmft/dfs), plaque (none, moderate, heavy), and oral hygiene (good, poor, unknown). Biospecimens (supragingival plaque, saliva, stool) were collected to evaluate associations with microbiota characteristics. Data were descriptively analyzed. Correlation analyses are pending.

Results: Among those with caries, dmfs ranged 1-26 (mean=8.5, SD=7.95). 29.17% of children (n=7) had “poor” oral hygiene (n=5, 71.43% with caries); 45.83% (n=11) “good” (n=7, 63.64% with caries); and 25% (n=6) unknown (n=2, 33.33% with caries). 29.17% (n=7) had history of antibiotic use (n=5, 71.43% with caries); 16.67% (n=4) prescription medications (n=1, 25% with caries); and 66.67% (n=16) OTC (n=8, 50% with caries). 4.17% (n=1) of children reportedly used all three and had caries. Analysis of associations with microbial characteristics are forthcoming.

Conclusions: Though limited by a small sample, p</span>reliminary findings suggest most preschool-age children have exposure to pharmacologics. Understanding its relationship to oral health may provide insight into caries risks.  


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