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Caries

Antimicrobial, Remineralization, and Staining Effects of Nano-Silver-Fluoride

7 - Antimicrobial, Demineralization inhibition potential and Staining effects of Nano Silver-Fluoride

Friday, May 23, 2025
10:00 AM - 10:20 AM MDT
Has Audio

    Presenting Author(s)

  • Quiesly Torres, DDS (she/her/hers)

    Resident
    University of Alabama at Birmingham
    University of Alabama at Birmingham
    Birmingham, Alabama, United States

    • Research Mentor(s)

  • Yu-Yin Lin, D.D.S.

    Assistant Professor | Director, Pre-Doctoral Program in Pediatric Dentistry
    University of Alabama at Birmingham
    University of Alabama at Birmingham
    Birmingham, Alabama, United States

    • Program Director(s)

  • JJ

    Janice G. Jackson, DMD

    Professor & Chair Department of Pediatric Dentistry
    University of Alabama at Birmingham
    birmingham, Alabama, United States

Abstract:



Purpose: Silver diamine fluoride (SDF) has emerged as an effective agent in caries arrest and/or prevention. However, due to its side effect of unesthetic staining, other anticaries agents have been developed. This study aims to compare the in vitro antimicrobial activities, remineralization potentials, and staining effects of Nano-Silver-Fluoride (NSF) with SDF and a water-based silver fluoride solution.



Methods: NSF-chitosan solution containing 1500 ppm NSF (Nano Research Elements, India) was compared with Advantage Arrest SDF 38% (Elevate Oral Care, USA) and Riva Star Aqua (RSA) water-based silver fluoride 38% (SDI Limited, Australia). The antimicrobial activities of the three materials against Streptococcus mutans UA159 and Candida albicans SC5314 were assessed using an agar diffusion assay, colony counting assay, and minimum inhibitory concentration assay. The remineralization potentials and the staining effects of the materials were done on bovine bone disks following acid-induced demineralization, and evaluated by microhardness analysis and imaging analysis, respectively.



Results: The antimicrobial activity of the NSF against S. mutans and C. albicans was not as strong as SDF and RSA; however, all the tested materials showed significant antimicrobial effects compared to the negative control. While NSF and RSA showed minimal staining on the bone slices compared with SDF, SDF presented the strongest remineralization potential.



Conclusions: Although the NSF used in the present study is not as effective as the other two silver fluoride agents in the antimicrobial effects against S. mutans and C. albicans, the non-staining benefit of NSF warrants further modification for better antimicrobial and remineralization effects.

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