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Sedation

Effectiveness of Intranasal Flumazenil Following Paradoxical Reaction to Midazolam Sedation

174 - Effectiveness of Flumazenil as a Reversal Drug

Friday, May 23, 2025
3:40 PM - 4:00 PM MDT
Has Audio

    Presenting Author(s)

  • Lauren Bartnicki, DMD

    Pediatric Dental Resident - PGY2
    UPMC Children's Hospital of Pittsburgh
    UPMC Children's Hospital of Pittsburgh
    Pittsburgh, Pennsylvania, United States

    • Research Mentor(s)

  • MC

    Mary Chapman, DDS

    Attending, Research Mentor
    UPMC Children's Hospital of Pittsburgh
    Pittsburgh, Pennsylvania, United States

    • Program Director(s)

  • HB

    Heather Baumhardt, DDS

    Program Director
    UPMC Children's Hospital of Pittsburgh
    Pittsburgh, Pennsylvania, United States

Abstract:

Purpose: The aim of this study was to analyze patients reversed with flumazenil following midazolam administration and subsequent paradoxical reaction at UPMC Children’s Hospital of Pittsburgh over a span of six years and determine how many minutes were observed until effective recovery was concluded and compare these times to the different age groups.

Methods: Charts of 11 total patients recorded to have been given intranasal flumazenil as a reversal after midazolam administration from 12/21/2018 to 4/22/2024 were reviewed. The age range of the children was 4 to 9 years old (median age, 6 years).

Results: There was a statistically significant difference between age and minutes of recovery as determined by one-way ANOVA (F(1,22) = 23.95, p < 0.05)”).

Conclusion: Younger patients had significantly longer recovery times after intranasal flumazenil administration. The mean recovery time amongst all age groups was 33 minutes.

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