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Caries

141 - Enhanced Proximal Caries Remineralization Using a Novel Fluoride Delivery Device

Friday, May 23, 2025
2:20 PM - 2:40 PM MDT
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Abstract:

Purpose:  The aim of this study was to evaluate the efficacy of a novel device, Cav-Aid, in enhancing the remineralization of initial proximal caries compared to traditional fluoride treatments.




Methods:  Initial caries lesions were created on 120 bovine enamel blocks using a microbial caries model. Blocks were randomly assigned to six treatment groups: artificial saliva only (AS), Cav-Aid only (CA), Cav-Aid combined with daily fluoride toothpaste (CA+F), fluoride varnish applied by flossing (FV-Floss), fluoride varnish applied by interdental painting (FV-Paint), and daily fluoride mouthrinse (F-Mouthrinse). Samples underwent a 14-day pH-cycling protocol alternating between artificial saliva and acidic buffer. Surface microhardness (SMH) was measured at baseline, post-demineralization, and post-remineralization. Paired t-tests were conducted to evaluate intra-group changes, and one-way ANOVA with Tukey’s HSD was used for inter-group comparisons (P < .05).




Results:  Following remineralization, paired t-test revealed significant (P < .001) increases in SMH within all treatment groups. CA+F showed the highest remineralization (37%), significantly (P < .001) outperforming all other groups, except Cav-Aid Only. CA (29%) followed, demonstrating strong remineralization efficacy, as a single-modality treatment, significantly greater than all other groups, except CA+F. There was no significant difference in remineralization among FV-Paint (15%), FV-Floss (13%), F-Mouthrinse (8%), and AS (5%), except between AS and FV-Floss (P < .05).




Conclusion:  Cav-Aid, particularly when combined with daily fluoride toothpaste, significantly enhanced remineralization of proximal caries compared to traditional fluoride treatments. These findings highlight the potential of a targeted delivery system, like Cav-Aid, in optimizing fluoride efficacy, particularly in interproximal regions.


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