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Growth & Development

29 - Molar Incisor Hypomineralization and Dental Anomalies: A Case-Control Study

Friday, May 23, 2025
10:40 AM - 11:00 AM MDT
Has Audio

    Presenting Author(s)

  • Juno Park, DDS

    Pediatric Dental Resident
    University of Illinois at Chicago, Chicago IL
    University of Illinois at Chicago, Chicago IL
    Chicago, Illinois, United States

    • Research Mentor(s)

  • AT

    Azza Tagelsir Ahmed, PhD, MSc, BDS

    Clinical Associate Professor
    University of Illinois at Chicago, Chicago IL
    Chicago, Illinois, United States

    • Program Director(s)

  • Brittaney J. Hill, DDS, MS, MPH

    Clinical Associate Professor and Residency Program Director
    University of Illinois Chicago, Chicago IL
    University of Illinois at Chicago
    Chicago, Illinois, United States

Abstract:



Purpose: To evaluate the association between Molar Incisor Hypomineralization (MIH), early-life adverse environmental and medical events, and co-existing developmental dental anomalies (DDA).



Methods: This case-control study included children aged 6–13 years, with the presence of MIH serving as the inclusion criterion for the case group. Each child with MIH was matched with a child without MIH of similar age and demographic characteristics to form the control group. Trained and calibrated examiners assessed MIH using standardized diagnostic criteria. Biological mothers completed a structured questionnaire addressing pregnancy and early-life adverse events. DDA were identified through clinical and radiographic assessment. Statistical analyses included descriptive statistics, Chi-square and Fisher’s exact tests, and logistic regression.



Results: A total of 56 children were enrolled, including 28 in the MIH group and 28 in the control group. The mean age was 9.32 ± 1.89 years in the MIH group and 8.24 ± 1.46 years in the control group. Among the MIH group, 89.3% were born in the United States compared to 96.3% in the control group, and 70.4% were Hispanic or Latino compared to 78.6% in the control group. Developmental dental anomalies were significantly associated with MIH (χ² = 6.76, P = .0093). No significant differences were found in pregnancy, environmental, and early-life adverse events between the MIH and control groups (P > .05).



Conclusions: This preliminary study demonstrates a significant association between MIH and the presence of DDA. Further research with larger sample sizes is needed to confirm these findings.

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