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Caries

274 - Mouthwash for Children That Targets Streptococcus Mutans Biofilms

Saturday, May 24, 2025
11:30 AM - 11:45 AM MDT
Has Audio
Abstract: The early stages of dental caries involve Streptococcus mutans adhering to teeth, forming biofilms, and producing enamel-damaging acids. The S. mutans enzyme sortase A (SrtA) is crucial for bacterial adhesion, making it a key target for plaque prevention. We found that polyphenolic compounds from maple extracts, including (-)-epicatechin gallate (ECG), inhibit SrtA. ECG is also abundant in green tea. Computational models showed ECG binds to the enzyme’s active site, and in vitro studies confirmed it reduces SrtA activity. At 100 µM, ECG significantly impaired bacterial attachment and biofilm formation on saliva-coated hydroxyapatite, simulating tooth enamel. These findings suggest ECG as a safe, affordable option for preventing caries, particularly in children who may avoid antimicrobial based products due to safety concerns, if ingested. This natural compound offers a promising alternative for maintaining oral health and could be used in a safe to swallow oral rinse. 

Identify Supporting Agency and Grant Number: Research supported by the National Institutes of Health (NIH).